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Founded in the 1530s, Ecuador's largest city and main port is the top access point for Galapagos cruises and home to a bustling import-export business. Tourism is on the rise as well, thanks to a new international airport and urban renewal projects along the River Guayas promenade and in the historic neighborhood of Las Peñas. The 465-step climb to the top of Santa Ana Hill provides sweeping views and a chance to stand on the site of the city's birthplace.