This place is a gem! We were only in San Diego for two days thus could only check out two spots for dinner. We visited Civico 1845 on our first night in SD and had one of the most splendid meals of our road trip.
For mains I had a beautiful clam, broccoli and garlic fettuccine. The pasta was perfectly cooked, the clams were sweet and salty, and the whole dish was balanced and well seasoned. My friend had the seafood linguine which was generously portioned with the "fruits of the sea" - namely shrimp, clams and mussels. It's nice to see a restaurant that is not miserly with seafood.
For desserts I had a chocolate cake with pistachio gelato. In a nutshell - it was divine. The cake was rich and the gelato was beautiful and not overly sweet as gelato can be. My friend had the tiramisu which was also well reviewed.
The place was very busy and I would recommend booking, if possible. The service was friendly and efficient but not overbearing - this is authentically Southern European table service and just how I like it.
Overall, although this place is by no means cheap, it is fairly priced. For the above described meal inc. complementary bread, two lovely glasses of Pinot Noir and service came to around $110. A fair price for an excellent meal.