For those that are not self driving, to reach the hotel from the Otogar (bus station), you can take one of the dolmus (mini-van) going from Denizli to Pamukkale and just tell the driver you're going to the Venus Hotel and the mini van will drop you at the crossroad just outside of the hotel.
This hotel is a jem in Pamukkale, very beautiful hotel with spacious room and great garden. My friend said thier breakfast is one of the best she's had in Turkey. Everyone at the reception is nice and friendly, though sometimes communication may be a little hard but all was resolved. Many tourist coming to Pamukkale don't stay here for a night, but I highly recommend to spend a night in Pamukkale, it's a tranquil and natural little town worthy of staying.More