Your two best options are taking 64 to 81 to 77 to 20 into SC, or taking 29 south to 85 to 77 to 20. The advantage of taking 29 down into NC is it's the most direct route and is 30 miles shorter than the 81 route, but 81 is more of a major highway where you're going to make better time. That being said, 29 is still a highway that'll have you driving 65/70 most of the way and it's a little more scenic. Plus 81 can get a little backed up with traffic sometimes that'll limit you to 55 or so. I think either route would work okay.
yeah btwn 6 and 7 I would guess.
I drive to Greenwood, SC frequently from Charlottesville. I agree with taking 29S. I-81 is a nightmare.
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