It's not a great area, but if you avoid walking around at night and use normal big city safety precautions you should be okay.
I'd look elsewhere, personally.
Spring Hill Suites Tempe is very close to Arizona Mills Mall which will provide you with many dining/shopping options, but the area is not the best (also not the worst). With that said, if you take normal precautions you should be fine. I have walked around that area at night without any issues.