Hi... what is the best way to go from Munich to Karlovy Vary in late November?
No direct or easy way..will require at least 2 changes.
Idos.cz for timetable for bus/train, connections
Train with changes in Nurnberg and Cheb. This will take 4 hours.
You could do it with one change only via Prague but that would take twice as much time so it's unreasonable unless you want to stop over in Prague.