It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita?

Dubrovnik, in the extreme south of Croatia, is known as the Pearl of the Adriatic. A rich and powerful city state until 1806, the proud city once known as Ragusa has a population of over 120,000. Structural damage suffered during the siege of 1991 and 1992, at the hands of the Yugoslav People's Army, has been repaired and visitors once again flock to this tranquil city, nestled between the Adriatic and Dinaric Alps. A wealth of sites lies within the walls of the pedestrian-only Old Town.

Land of Mermaids. Land of Orange and Lemon Groves. Land of Colors. This small city in Campania has earned a plethora of alluring names. Famed for its sea cliffs, the town's steep slopes look out over azure waters to Ischia, Capri and the Bay of Naples. The birthplace of Limoncello liqueur offers some good diving, great sea fishing, boat cruises and appetizing restaurants. Excellent hiking trails cross the peninsula. Rent a car or take a taxi if the steep streets look too intimidating.

Stretching along the southern side of Italy's Sorrentine Peninsula, the Amalfi coast dazzles with its mysterious grottos, craggy cliffs and shimmering bays. Grab a seat on the sea side of a regional bus to soak up views on the fabled route from artsy Positano to Amalfi. Ravello offers some respite from the crowds, plus the stunning Villa Cimbrone, which overlooks the Bay of Salerno. The winding streets of Sorrento's historic district are filled with craftspeople. Capri is only a hydrofoil or ferry ride away.