Casinos, naturally, continue to draw tourists to Las Vegas. From penny slots to high-stakes table games in private salons, you'll find it here. But there's much more to Las Vegas than gambling. Our weekend itinerary highlights attractions of a different sort, from the choreographed fountains at the Bellagio to the Liberace Museum. Las Vegas is also surprisingly family-friendly. In an attempt to appeal to kids, the hotels have spent millions developing technically sophisticated indoor amusement rides such as the Race for Atlantis.

A few years ago San Francisco was riding high on the wealth of the dot com explosion. And it showed in outrageously high-priced hotels, restaurants and real estate. When the bubble burst, the city was forced to adjust. In fact, now is a great time to visit the somewhat humbler, but just as fabulous, cultural mecca of the Left Coast. Hotels and restaurants have lowered their prices, making it easier to enjoy a weekend here. One of the best things about San Francisco is that you can be in a museum in the morning and on a mountain in the afternoon. Mind-expanding cultural attractions exist alongside invigorating outdoor activities. Gaze at the work of Jackson Pollock at the San Francisco Museum of Modern Art in the morning and then head to Muir Woods to peer up at gigantic redwoods in the afternoon. From the hippie haunts of Haight-Ashbury to the colourful Victorian architecture of the predominantly gay Castro District, and from Japantown to Chinatown, San Francisco is all about neighbourhoods. Each has a distinct look and vibe; you could easily spend a day in each or hop on a streetcar to sample a few.

With attractions and activities galore, Chicago is everyone's kind of town. See all the famous sights, then go to a show in the theatre district or a Cubs game at historic Wrigley Field, followed by a late-night visit to a blues club or jazz bar. Culture hounds will delight in the multitude of museums, including the prestigious Art Institute and the Chicago Historical Society. Families will find plenty to do at Navy Pier and plenty to explore at the Field Museum and the Lincoln Park Zoo. You could spend all day strolling through Hyde Park or shopping along the Magnificent Mile. Discover vibrant ethnic neighbourhoods, architectural landmarks, delicious food and world-class hotels. From the top of the Sears Tower to the shores of Lake Michigan, Chicago offers so much to do, visitors keep coming back for more.

Helen, a Bavarian Alps replica town in Appalachian Georgia, is home to an Oktoberfest for the ages, overflowing with two-litre beer glasses and Germany's famous bratwursts.  To recover from the festivities, the savviest make their way to Cedar Creek Luxury Cabins on the edge of the Chattahoochee National Forest.

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.

From the National Mall’s monuments and memorials to vibrant neighbourhoods filled with character and charm, DC is a world-class destination featuring breathtaking views, award-winning hotels and hundreds of free things to do. Experience outstanding performing arts at acclaimed theatres, shop in historic Georgetown, hear great live music at legendary venues, enjoy sporting entertainment from six professional franchises and be dazzled by a flourishing dining scene with Michelin-starred restaurants.

The farther you go from Grand Cayman's busy docks, the more peace and quiet you'll find. At Stingray City (actually a sandbar), stingrays swim alongside you in the tranquil waters. Closer to town, travellers report finding some of the best massage and spa services anywhere in the Caribbean.

Whether it's your first visit or your 50th, New York City is a great destination for a weekend trip. See the landmark sights, catch a Broadway show or explore small, off-the-beaten-path museums like the Lower East Side Tenement Museum. Just as it has activities to suit every interest, New York City has hotel options to suit every pocket. Whether you're looking for a hip new hotel, an old standard or a budget inn, you'll have plenty of options.

Famous for everything from the Red Sox and Paul Revere to Cheers and clam "chowdah", Boston is a popular destination for so many reasons. Part history lesson, part modern metropolis, the Hub offers attractions to suit every taste and interest. It's also incredibly easy to get around, either on foot or on the user-friendly public transport system, called the T. The Freedom Trail, a well-preserved pedestrian path, weaves in and out of historic neighbourhoods, from the lively Boston Common and Public Garden to the gold-domed State House and Fenway Park. Between landmarks, you can shop in the fabulous stores on Newbury Street, have a delicious Italian meal in the North End or browse the antique shops and distinctive red-brick buildings of Beacon Hill. The more culturally inclined will not want to miss the city's world-class museums, theatres and music venues. Family friendly to the core, Boston also boasts a renowned aquarium, children's museum and science museum, making it a great break destination for all.