Famed for its football team and music scene, which has produced the likes of The Smiths and Oasis, this centre for sports and the arts is a down-to-earth and friendly city. The so-called Capital of the North has overcome industrial decline, bombing (in WWII and by the IRA) to become a confident and cosmopolitan city of well over two million. It is well served by a bus and light rail network. Top attractions include the Lowry art complex, arcade Affleck's Palace and Canal Street gay village.

You've probably heard that Guinness tastes better in Dublin (fresh from the factory), but what you may not know is that Dublin is a perfect destination for the whole family. No, we're not suggesting you let the kiddies drink a pint. Instead, take them to the Dublin Zoo, to feed the ducks in Stephen's Green or on a picnic in Phoenix Park. Scholars enjoy walking in the literary footsteps of such writers as Yeats and Joyce, while discerning shoppers have their pick of designer boutiques.

Kilkenny is over 400 years old, but it sure doesn’t show its age. Yes, it's an awe-inspiring throng of medieval cathedrals, castles, abbeys and other massive stone buildings, but Kilkenny loves to party. An endless stream of arts festivals celebrating theater, comedy, bluegrass and dance is constantly pumping the city with new life, toe-tapping energy and international flavor.

Plan to cross many bridges when in Cork. Ireland's third-largest city began life as an island and now spans both banks of the River Lee, with watery channels running beneath some of its main thoroughfares. The best way to experience this hilly southern seaport is on foot, following the signposted walking tour past St. Finn Barre's Cathedral and the riverside quadrangle of University College up the hill to red and white Shandon Church. Along the way, you'll meet plenty of the city's talkative residents.

It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita?

Get to Matera quickly, because it’s still relatively undiscovered by foreign tourists. In town, visit the Domenico Ridola National Museum. Matera’s real claim to fame, though, and the reason it’s a UNESCO World Heritage Site, is the extensive series of cave dwellings ("i sassi") southeast of town, first inhabited by Benedictine and Basilian monks. You’ll see individual cells, chapels, and even some churches, many adorned with Byzantine decorations and frescoes.