Dubrovnik, in the extreme south of Croatia, is known as the Pearl of the Adriatic. A rich and powerful city state until 1806, the proud city once known as Ragusa has a population of over 120,000. Structural damage suffered during the siege of 1991 and 1992, at the hands of the Yugoslav People's Army, has been repaired and visitors once again flock to this tranquil city, nestled between the Adriatic and Dinaric Alps. A wealth of sites lies within the walls of the pedestrian-only Old Town.

One of the most popular regions in Italy, Tuscany stretches from the Tyrrhenian Sea to the Apennines. Its main cities include Florence, Pisa, Siena, Lucca, Arezzo and Livorno. Drive between stunning sites like Florence's cathedral and Uffizi Gallery and the Leaning Tower of Pisa. Or join a bike tour and pedal past sun-baked olive groves and vineyards. Don't miss the towers of San Gimignano or serene northern hill towns. For a more modern take, hit one of Florence's hip clubs, such as Space Electronic.

A patchwork of vineyards and olive groves, dotted with whitewashed hill towns and sun-bronzed beaches—Italy’s southern heel has no shortage of photogenic landscapes. There are a few surprises, too, including the baroque city of Lecce and the Itria Valley, with its UNESCO-listed trulli houses.

Stretching along the southern side of Italy's Sorrentine Peninsula, the Amalfi coast dazzles with its mysterious grottos, craggy cliffs and shimmering bays. Grab a seat on the sea side of a regional bus to soak up views on the fabled route from artsy Positano to Amalfi. Ravello offers some respite from the crowds, plus the stunning Villa Cimbrone, which overlooks the Bay of Salerno. The winding streets of Sorrento's historic district are filled with craftspeople. Capri is only a hydrofoil or ferry ride away.

Stroll Las Ramblas and enjoy Barcelona's unique blend of Catalan culture, distinctive architecture, lively nightlife and trendy, stylish hotels. You'll find Europe's best-preserved Gothic Quarter here, as well as amazing architectural works by Gaudi. La Sagrada Familia, considered Gaudi's masterpiece, is still under construction (your entrance fee helps to fund the project). Feel like a picnic? Look no further than the rambunctious La Boqueria market, where you can stock up on local delicacies.

Attracting visitors from all parts of the world, Majorca is a dreamy island destination in the Mediterranean Sea, just off the southeast coast of Spain. There's something for every taste—beaches and coves, a spectacular mountain range, romantic fishing villages and a rustic countryside dotted with almond and olive groves.

Spain's third-largest city, Valencia basks on the Mediterranean coast south of Barcelona. Amid rugged mountains and glorious orange groves, the city boasts impressive futuristic architecture, neon-lit fountains, a colorful old town and a bustling beach. The easiest way to explore the city is on the fast, efficient metro trains or, in the central areas, on foot. For a real taste of Valencia, try its famous nightlife, arrive during March's Las Fallas festival or try local firewater, Agua de Valencia.

The Costa del Sol juxtaposes gorgeous Mediterranean old towns and inland national parks with developed beach resorts. Famed for being the birthplace of Picasso, Malaga serves as a gateway to family-favourite stops such as Benidorm and Fuengirola.

The Algarve's sunny shores offer perfect escapes for all types, from those seeking the hot nightlife of flashy, energetic Lagos to those desiring secluded stays in rambling Sagres. Portugal's most southerly region offers historical attractions in former Moorish capital Silves and fascinating Tavira, great golf, fabulous beaches from Praia da Luz to Armacao de Pera, thermal springs at Caldas de Monchique, and miles of limestone caves and grottoes, cliffs and bays along its rugged coastline.