"The City of Tribes" provides a fun blast of the Ireland many first-time visitors expect. The compact city centre, with its winding streets, packed pubs and air of celebration, is easily walked - or pubcrawled. The west-coast city of almost 70,000 is home to merry bands of students, artists, writers and craftspeople, and is merriest during summer's Galway's Arts Festival. Don't miss shopping for Claddagh rings, the Druid Theatre or having a pint o' the black stuff at the atmospheric Tigh Neachtain pub.

Belfast has grown into a cosmopolitan city and become a popular weekend-break destination. The city pulses with an irrepressible optimism and energy. The Northern Ireland capital has an increasing number of intriguing bus, taxi, boat and pedestrian tours. Attractions such as Ulster Folk Museum and Belfast Cathedral, award-winning restaurants, lively bars from modern lounges to traditional pubs, hip clubs, great shopping, impressive theatres, galleries and live music make it a vivacious destination.

Don your most comfortable shoes for Killarney, where town trails offer history lessons and country walks traverse Ireland's first national park: 26,000 acres of woodlands, sandstone mountains and low-lying lakes. In the town centre, Killarney House and Gardens provide a break for urban explorers. Renowned Muckross House, with its 15th-century abbey ruins and massive yew tree, is just outside the town. If your feet wear out, take in Killarney National Park's legendary scenery from a boat trip from Ross Castle.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Amsterdam is truly a biker’s city, although pedaling along the labyrinthine streets can get a little chaotic. Stick to walking and you won’t be disappointed. The gentle canals make a perfect backdrop for exploring the Jordaan and Rembrandtplein square. Pop into the Red Light District if you must—if only so you can say you’ve been there. The Anne Frank House is one of the most moving experiences a traveller can have, and the Van Gogh Museum boasts a sensational collection of works.

In progressive Berlin, the old buildings of Mitte gracefully coexist with the modern Reichstag. Don't miss top historic sights like the Berlin Wall, Checkpoint Charlie, the Brandenburg Gate and Potsdamer Platz. The city's great zoo makes for a fun break from touring the staider attractions.

Stroll Las Ramblas and enjoy Barcelona's unique blend of Catalan culture, distinctive architecture, lively nightlife and trendy, stylish hotels. You'll find Europe's best-preserved Gothic Quarter here, as well as amazing architectural works by Gaudi. La Sagrada Familia, considered Gaudi's masterpiece, is still under construction (your entrance fee helps to fund the project). Feel like a picnic? Look no further than the rambunctious La Boqueria market, where you can stock up on local delicacies.

We hear the question, "What’s the next Prague?" a lot. But while we’re all for discovering great new destinations, we hardly think Prague is over. Sure, everyone’s heard of it, but it’s still a grand city with extraordinary historic and cultural sights, and it’s definitely worth a visit. The often-rebuilt Prague Castle has overlooked the city since the 9th century, and the synagogues and cemetery of the Jewish Quarter are must-sees. Nightlife here is diverse and plentiful, from trendy clubs to sophisticated wine bars to late-night cellar bars.

The Algarve's sunny shores offer perfect escapes for all types, from those seeking the hot nightlife of flashy, energetic Lagos to those desiring secluded stays in rambling Sagres. Portugal's most southerly region offers historical attractions in former Moorish capital Silves and fascinating Tavira, great golf, fabulous beaches from Praia da Luz to Armacao de Pera, thermal springs at Caldas de Monchique, and miles of limestone caves and grottoes, cliffs and bays along its rugged coastline.