Campo dei Miracolo and Pisa's precarious tower are the main reason people visit this Tuscan city that traces its history back to around 1000 B.C. The grand buildings are relics of the former republic of Pisa's maritime might. Visitors can climb the Tower's 300 steps for a tilted view. Other spots in the city where Galileo was born include the National Museum of San Matteo and Camposanto cemetery. Local bus tickets can be bought at tabacs. An excellent rail network links Pisa with other Tuscan cities.

San Gimignano, known as the "city of beautiful towers," had 72 towers in its heyday. Now 14 remain, and, rising above Tuscany's Elsa Valley, they make the town look like a mediaeval dreamscape. Take in the fresco-covered Collegiate Church, the Civic Museum and the views from atop 177-foot Torre Grossa. Daytrippers from Florence tend to fill up the streets during the day, so for a more up-close-and-personal look at the town, spend the night.

Wandering the narrow caruggi alleyways of Genoa is a bit like solving a medieval labyrinth. In the heart of the Italian port city lies Piazza de Ferrari, a main square with a beautiful fountain and a perimeter lined with historic buildings, including the Palace of the Doges the Teatro Carlo Felice, which was destroyed during WWII and subsequently rebuilt. The seaside neighborhood of Boccadasse is vision of pink and yellow buildings that brighten up this lovely fishing village.

While crowds of tourists fill Venice, Florence and Rome, Bologna remains relatively quiet in comparison. This mediaeval university town is charming, historic and fun to explore… and you'll find Bologna's local cuisine is light-years away from the American deli meat bearing the city's name.

Nice has a cosmpolitan Riviera vibe, and you'll enjoy exploring its fashionable boutiques and restaurants and sunning yourself on its popular beaches. (Just don't expect soft sand—these beaches have pebbles.) Walk up to Castle Hill for a beautiful view of the city, the Bay of Angels and of course, the bright blue water that gave the Cote d'Azur its name.

The second most populous town in North Germany, Bremen brings the high-tech, science and space industries together beneath a truly metropolitan backdrop. In a city where innovation, beauty and sophistication meet, it's impossible not to feel the life force. In this 1,200-year-old Hanseatic city, visit the Schlachte Promenade on the River Weser, the full-sized Columbus Space Module of the International Space Station and the Universum Science centre. Oh, and "Hanseatic" refers to an alliance of trading cities in the 13th-17th centuries. But you probably knew that.