As the meeting point of the Rhine and Mosel rivers and with the UNESCO-listed Rhine Valley as its backdrop, Koblenz has no shortage of photo-worthy scenery. Add a hilltop medieval fortress and some impressive Romanesque buildings, and it's one of the prettiest towns along the Rhine.

Two thousand years of history have lent Mainz a cosmopolitan air, and museums and cathedrals of various architectural styles dot the city. Bring home a book as a souvenir—Gutenberg worked here, and the museum dedicated to him is a highlight.

Roman legions marched into what is now the Rhineland's largest city in 38 B.C. These two thousand years have produced a wealth of sites to visit, from Roman towers to Gothic churches to modern architecture. With a reputation as a fine art center, Cologne has museums running the gamut from the Museum of Applied Art to Museum Ludwig, home to works by Warhol and Picasso, to the Chocolate Museum. The city has an excellent bus, tram and train system, on which Kolner Tageskarte, Day Tickets, are valid.

Home to the oldest university in Germany, Heidelberg suffered during 17th-century wars and was rebuilt in the 18th century, using the old Gothic street layout but with Baroque buildings. The historic city centre's Gothic streets are easy to navigate on foot. Fourteenth-century Heidelberg Castle is the symbolic heart of the city. The Alte Brucke is a beautiful 18th-century bridge. This university town also has a historic Student Jail, for visitors who take their history and education seriously.

It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita?

You've probably heard that Guinness tastes better in Dublin (fresh from the factory), but what you may not know is that Dublin is a perfect destination for the whole family. No, we're not suggesting you let the kiddies drink a pint. Instead, take them to the Dublin Zoo, to feed the ducks in Stephen's Green or on a picnic in Phoenix Park. Scholars enjoy walking in the literary footsteps of such writers as Yeats and Joyce, while discerning shoppers have their pick of designer boutiques.

Kilkenny is over 400 years old, but it sure doesn’t show its age. Yes, it's an awe-inspiring throng of medieval cathedrals, castles, abbeys and other massive stone buildings, but Kilkenny loves to party. An endless stream of arts festivals celebrating theater, comedy, bluegrass and dance is constantly pumping the city with new life, toe-tapping energy and international flavor.

There once was an Irish city… You might think "naughty poem" when you hear the word Limerick, but in truth the city inspires so much more than just knowing giggles. Medieval castles and churches give the city a grand feel, while the pubs crawl with lively locals and students who are all craving just one more pint of Guinness. The Hunt Museum boasts a collection of pieces from history's most important and influential artists, while the Foynes Flying Boat Museum will marvel visitors of all ages with its whimsical flying machines.

Originally founded as a Roman city and now home to three UNESCO World Heritage Sites, Seville is bursting with antique charm. The Alcazar palace complex is a stunning collage of architectural styles, and the Cathedral will impress you with its beauty and its status as the burial site of Christopher Columbus. The Metropol Parasol is the world’s largest wooden structure, a massive mix of grids and swirls that contains a market and a terrace observatory.

Spartanburg offers a unique blend of small-town charm and big-city energy, making it a must-visit destination in the Southeast. Unlike other fast-growing cities, Spartanburg’s growth enhances its appeal without sacrificing its inviting, crafted atmosphere. With the Spartanburgers minor league baseball team, scenic outdoor trails and a vibrant downtown, Spartanburg is transforming in ways that delight first-time visitors and returning guests. Conveniently located between Atlanta and Charlotte, Spartanburg provides easy access to outdoor recreation in the picturesque foothills of the Appalachians, along with a dynamic dining, shopping and entertainment scene.