A magnet for skiers and hikers, these dramatic peaks – including the iconic Matterhorn – range from 3,000 to 15,000 feet and spread across three-fifths of the country. Abundant glaciers, scenic valleys and gorgeous alpine lakes add to the region's visual appeal. The Glacier Express train travels the 7.5-hour route through the Swiss Alps from Zermatt to St. Moritz, passing through fairy-tale villages and over 291 bridges along the way.

Milan is the prime draw in Italy's most prosperous province. The Cathedral, La Scala opera house and Santa Maria delle Grazie, home of da Vinci's Last Supper, are just some of the sights. Equally fascinating is the belle poque splendor of 19th-century Galleria Vittorio Emanuele II. When not on one of its frequent strikes, Milan's Metro is an excellent way to explore. Renting a car opens up the region, with its towns full of Romanesque architecture and the peninsula of Sirmione and Gardesana coast.