It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita?

Amsterdam is truly a biker’s city, although pedaling along the labyrinthine streets can get a little chaotic. Stick to walking and you won’t be disappointed. The gentle canals make a perfect backdrop for exploring the Jordaan and Rembrandtplein square. Pop into the Red Light District if you must—if only so you can say you’ve been there. The Anne Frank House is one of the most moving experiences a traveller can have, and the Van Gogh Museum boasts a sensational collection of works.

Everyone who visits Paris for the first time probably has the same punchlist of major attractions to hit: The Louvre, Notre Dame, The Eiffel Tower, etc. Just make sure you leave some time to wander the city’s grand boulevards and eat in as many cafes, bistros and brasseries as possible. And don’t forget the shopping—whether your tastes run to Louis Vuitton or Les Puces (the flea market), you can find it here.

Spain's third-largest city, Valencia basks on the Mediterranean coast south of Barcelona. Amid rugged mountains and glorious orange groves, the city boasts impressive futuristic architecture, neon-lit fountains, a colorful old town and a bustling beach. The easiest way to explore the city is on the fast, efficient metro trains or, in the central areas, on foot. For a real taste of Valencia, try its famous nightlife, arrive during March's Las Fallas festival or try local firewater, Agua de Valencia.

You've probably heard that Guinness tastes better in Dublin (fresh from the factory), but what you may not know is that Dublin is a perfect destination for the whole family. No, we're not suggesting you let the kiddies drink a pint. Instead, take them to the Dublin Zoo, to feed the ducks in Stephen's Green or on a picnic in Phoenix Park. Scholars enjoy walking in the literary footsteps of such writers as Yeats and Joyce, while discerning shoppers have their pick of designer boutiques.

Plan to cross many bridges when in Cork. Ireland's third-largest city began life as an island and now spans both banks of the River Lee, with watery channels running beneath some of its main thoroughfares. The best way to experience this hilly southern seaport is on foot, following the signposted walking tour past St. Finn Barre's Cathedral and the riverside quadrangle of University College up the hill to red and white Shandon Church. Along the way, you'll meet plenty of the city's talkative residents.

There once was an Irish city… You might think "naughty poem" when you hear the word Limerick, but in truth the city inspires so much more than just knowing giggles. Medieval castles and churches give the city a grand feel, while the pubs crawl with lively locals and students who are all craving just one more pint of Guinness. The Hunt Museum boasts a collection of pieces from history's most important and influential artists, while the Foynes Flying Boat Museum will marvel visitors of all ages with its whimsical flying machines.

"The City of Tribes" provides a fun blast of the Ireland many first-time visitors expect. The compact city centre, with its winding streets, packed pubs and air of celebration, is easily walked - or pubcrawled. The west-coast city of almost 70,000 is home to merry bands of students, artists, writers and craftspeople, and is merriest during summer's Galway's Arts Festival. Don't miss shopping for Claddagh rings, the Druid Theatre or having a pint o' the black stuff at the atmospheric Tigh Neachtain pub.

Don your most comfortable shoes for Killarney, where town trails offer history lessons and country walks traverse Ireland's first national park: 26,000 acres of woodlands, sandstone mountains and low-lying lakes. In the town centre, Killarney House and Gardens provide a break for urban explorers. Renowned Muckross House, with its 15th-century abbey ruins and massive yew tree, is just outside the town. If your feet wear out, take in Killarney National Park's legendary scenery from a boat trip from Ross Castle.

Whether it's your first visit or your 50th, New York City is a great destination for a weekend trip. See the landmark sights, catch a Broadway show or explore small, off-the-beaten-path museums like the Lower East Side Tenement Museum. Just as it has activities to suit every interest, New York City has hotel options to suit every pocket. Whether you're looking for a hip new hotel, an old standard or a budget inn, you'll have plenty of options.