Chiriquí Province is a mountainous wonderland, located near the Barú Volcano. If you’re an adventure and nature lover, you’ll be right at home here, as the region offers everything from white-water rafting and kayaking to zip-line rainforest rides and hiking. More relaxed activities, such as coffee plantation tours and bird-watching, also are available here. To reach Chiriquí, you’ll likely pass through David, Panama’s third-largest city. If you choose to visit the Gulf of Chiriquí, you’ll find first-rate scuba diving, snorkeling, and other water sports that take full advantage of its marine location.

An archipelago off the northwest coast of Panama, Bocas del Toro is an eco-tourism favorite with English-speaking and other tourists traveling to this Central American country. Seven islands (including Isla Colón, Isla Carenero and Isla Bastimentos) comprise the land area, with Bocas Town its regional capital and the “big city” for those looking to shop, dine well, and explore nightlife. Adventure lovers will find plenty to keep them occupied, as scuba diving, snorkeling, sailing, surfing and hiking are first-rate. And if you’re more of a tour-goer, never fear—Bocas del Toro offers a host of them, ranging from sailing to Nivida Bat Cave tours.

Only real-deal surfers should brave the torrid waters of Puerta Viejo de Talamanca, known both for their beauty and for their dangerously strong riptides. Surf’s especially up at Salsa Brava and Playa Cocles. Not to fear—the rest of you water bugs can enjoy snorkeling, kayaking and diving in the calmer waters of Cahuita or Manzanillo. Rent a mountain bike to coast to Manzanillo for a full, fun experience.

For eco-tourists who crave adventure there are few places better than Parque Nacional Corcovado, a biodiverse smorgasbord of tropical rainforest, coastline and wildlife. Puerto Jimenez is a great base for those who wish to explore the park via one of several local touring companies, but it’s also got its own thing going on, including an impressive wildlife sanctuary, some lovely restaurants and an excellent local crafts shop.

Cuba's top beach destination sits on a 13-mile-long peninsula with powder soft sands lapped by waters of the Kawama Channel. Resort hotels teem along the shore that U.S. celebrities and gangsters, including Capone, discovered in the 1920s. Clubs and bars provide mojitos and merriment, after long days baking on the beach, golfing, diving or deep sea fishing. Rent a scooter or hop aboard an open-air tourist train or bus to see more of this stunning spot. Caves, keys and virgin forest add to the area's allure.

Whether it's your first visit or your 50th, New York City is a great destination for a weekend trip. See the landmark sights, catch a Broadway show or explore small, off-the-beaten-path museums like the Lower East Side Tenement Museum. Just as it has activities to suit every interest, New York City has hotel options to suit every pocket. Whether you're looking for a hip new hotel, an old standard or a budget inn, you'll have plenty of options.

Niagara Falls is a top destination with a split personality of sorts, being a citizen both of the United States and of Canada. Views are generally accepted to be better on the Canadian side, with more to do and Ontario's excellent wineries adjacent. Visit the Clifton Hill District and enjoy a Las Vegas-style dinner show at Greg Frewin Theatre. See the Falls from below aboard the Maid of the Mist or on a helicopter tour above. For other ideas on how not to experience the Falls, visit the Daredevil Museum.

Everything about Santa Monica sizzles, from hundreds of funky shops and restaurants to more than three miles of white sandy beach, to the multitude of celebrities zipping into the local airport and out on Montana Avenue. The subject of popular songs, movies and television shows ("Baywatch" was one of many filmed here), the city has a vibe like no other. Hollywood haute couture meets surfer chic meets hippie casual, and somehow it all works. A word of advice: ditch the car and walk everywhere. Santa Monica is small and prides itself on being pedestrian- and environmentally friendly. You won't need wheels at the auto-free Third Street Promenade, a stroller's paradise known for its multitude of cinemas, restaurants and street performers. Or at the famous and historic Santa Monica Pier, home to tempting smells from fast-food stalls and the solar-powered, nine-storey high Ferris wheel that has long been a symbol of the city. If your feet start to fail, hop on the electrically powered Tide Shuttle, a bus service that runs along the beach offering great views plus a ride to the artsy Bergamot Station and the Santa Monica Museum of Art, or your next spirited Santa Monica destination.

Spartanburg offers a unique blend of small-town charm and big-city energy, making it a must-visit destination in the Southeast. Unlike other fast-growing cities, Spartanburg’s growth enhances its appeal without sacrificing its inviting, crafted atmosphere. With the Spartanburgers minor league baseball team, scenic outdoor trails and a vibrant downtown, Spartanburg is transforming in ways that delight first-time visitors and returning guests. Conveniently located between Atlanta and Charlotte, Spartanburg provides easy access to outdoor recreation in the picturesque foothills of the Appalachians, along with a dynamic dining, shopping and entertainment scene.