A youthful, modern metropolis with a diverse population, Tel Aviv dates back to only 1909. Clubs, bars, a thriving arts community, gay life and beaches attract artists, musicians and young professionals to Tel Aviv's more secular scene. Its UNESCO-designated Bauhaus architecture has won the city the moniker "The White City". Walk, drive or take cabs between the cultural exhibition pavilions of Haaretz Museum, historic Independence Hall Museum, bustling Carmel Market and Old Jaffa's boardwalk.

Few places inspire such passion as Jerusalem. Its significance to Jews, Christians and Muslims endures. The Israeli capital's major sites include the Old City, the Wailing Wall, the Church of the Holy Sepulchre, Via Dolorosa, and the Dome of the Rock, the world's third-holiest Islamic shrine. The Old City is easily explored on foot. Away from the religious sights, jazz clubs, hip restaurants, arthouse cinemas and edgy theatre entertain Jerusalem's 725,000 inhabitants and constant stream of visitors.

Follow the mineral-rich muddy footprints of Herod, Solomon and Cleopatra to the legendary Dead Sea and resorts developed round its adjacent hot springs. This famed health destination, at the world’s lowest dry point, is known for helping with rheumatic and skin problems.

Amman's layered history is reflected in its diverse people and its varied architecture. The city is home to a multidenominational and multicultural population. Even within the midst of the ultra-modern commercial centre, there is evidence of its ancient roots, with colorful souks, Roman ruins, cultural museums and monuments painting a picture of the history of the region.

Once known for smog, traffic and tacky architecture, Athens is a city reformed thanks to fortunes brought by the 2004 Summer Olympics. Spotless parks and streets, an ultra-modern metro, new motorways, an accessible airport and all signs in perfect English make the city easily negotiable. Meriting more than a stopover en route to the islands, sophisticated Athens sites include many pillars of Western history, from the Acropolis to the Temple of Olympian Zeus, as well as treasures in the National Archaeological Museum.

Sprawling along the edge of the Thermaic Gulf, Thessaloniki is a seaside showcase of Greek history from ancient Roman and Byzantine ruins to the modern high-rises lining its beaches. Plus, after sundown, Greece’s cultural capital hums with some of the best nightlife options in the Aegean.

One of the three principal islands of the Maltese archipelago, the island of Malta is the largest of the chain. Its capital Valletta, a lively, bustling city with many buildings dating back to the 16th century, teems with cathedrals, palaces and forts. The impressive Grand Harbour offers a dramatic arrival. The top archaeological attraction is the UNESCO-designated Hypogeum temple ruins, a macabre, 5400-square-foot underground necropolis and the world's only underground prehistoric temple.

Belfast has grown into a cosmopolitan city and become a popular weekend-break destination. The city pulses with an irrepressible optimism and energy. The Northern Ireland capital has an increasing number of intriguing bus, taxi, boat and pedestrian tours. Attractions such as Ulster Folk Museum and Belfast Cathedral, award-winning restaurants, lively bars from modern lounges to traditional pubs, hip clubs, great shopping, impressive theatres, galleries and live music make it a vivacious destination.

Lanzarote’s largest resort area has much to offer visitors—in addition to the fine beaches, you’ll find casinos, great shopping, and tons of restaurant options. Puerto Del Carmen’s nightclubs and large hotels are a big draw for a youthful European crowd.

The Indian and colonial influences in this South African beach city can’t be missed, and the blend of cultures and architecture makes Durban unique in South Africa. Durban’s Golden Mile is a destination for surfers, families and fisherman, due to its blend of natural beauty and modern resort. Major-city attractions abound, making this a good destination for families and couples alike.