Ios embodies that classic Greek island ambiance—hillside clusters of blue-roofed white buildings, an amphitheatre, golden beaches that spill into the sapphire sea. The spindly windmills of Ios are like something from a storybook, and a visit to the Tomb of Homer (yep, that Homer) is an exercise in awed contemplation. When the sun goes down, party it up at one of Ios’ many electrifying nightspots. Favourites are Astra Cocktail Bar and the (kind of insane) alt-rock scene, The Orange Bar.

Oia is carved out of the cliffs, and visitors can see houses built for Venetian sea captains as well as the more typical "cave houses" of the villagers. You’ll find the pure white buildings with colourful roofs that are typical of Greek architecture, and you’ll probably enjoy poking around the town. But don’t breeze through in an hour—you must stay for the sunset. It’s legendary. Watch from a café, or, better yet, from a boat—you’ll be spellbound.

Known as the "Island of Colours" thanks to its jewel-coloured waters and building painted in vivid primary tones, the horseshoe-shaped island of Milos floats serenely in the Aegean Sea. It was here that the world-famous Venus de Milo statue was discovered. Though she now holds court at the Louvre, Milos has other beauties to admire. There are dozens of beaches, all different colours and all different combinations of sand, stone and shell. Explore the ancient theatre, catacombs and windmills in Tripiti village, then cap off your day with a cinematic sunset.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

You've probably heard that Guinness tastes better in Dublin (fresh from the factory), but what you may not know is that Dublin is a perfect destination for the whole family. No, we're not suggesting you let the kiddies drink a pint. Instead, take them to the Dublin Zoo, to feed the ducks in Stephen's Green or on a picnic in Phoenix Park. Scholars enjoy walking in the literary footsteps of such writers as Yeats and Joyce, while discerning shoppers have their pick of designer boutiques.

Belfast has grown into a cosmopolitan city and become a popular weekend-break destination. The city pulses with an irrepressible optimism and energy. The Northern Ireland capital has an increasing number of intriguing bus, taxi, boat and pedestrian tours. Attractions such as Ulster Folk Museum and Belfast Cathedral, award-winning restaurants, lively bars from modern lounges to traditional pubs, hip clubs, great shopping, impressive theatres, galleries and live music make it a vivacious destination.

Plan to cross many bridges when in Cork. Ireland's third-largest city began life as an island and now spans both banks of the River Lee, with watery channels running beneath some of its main thoroughfares. The best way to experience this hilly southern seaport is on foot, following the signposted walking tour past St. Finn Barre's Cathedral and the riverside quadrangle of University College up the hill to red and white Shandon Church. Along the way, you'll meet plenty of the city's talkative residents.

Don your most comfortable shoes for Killarney, where town trails offer history lessons and country walks traverse Ireland's first national park: 26,000 acres of woodlands, sandstone mountains and low-lying lakes. In the town centre, Killarney House and Gardens provide a break for urban explorers. Renowned Muckross House, with its 15th-century abbey ruins and massive yew tree, is just outside the town. If your feet wear out, take in Killarney National Park's legendary scenery from a boat trip from Ross Castle.