Welcome to the Holiday Inn Express & Suites in Hannibal, MO. We are conveniently located off Interstate 36 at the Shinn Lane exit making it a convenient choice for both business and leisure travelers. We are just walking distance from the Hannibal Regional Hospital, Hannibal Clinic, the James E Cary Cancer Center, and an array of dining options. The Holiday Inn Express & Suites is also in close proximity to the following major companies, BASF Corporation, Continental Cement, General Mills, Spartan LMP, and Watlow to name just a few. Hannibal's Historic Downtown is a short car ride away. Some of the local attractions are the Mark Twain Boyhood Home and Museums, the Mark Twain Cave, Mark Twain Riverboat, Hannibal Trolley Tours, Rockcliffe Mansion, and Haunted Hannibal Ghost Tours.