Home to the Netherlands’ oldest university and the birthplace of Rembrandt, Leiden also served as a several-year stop-off between England and the New World for America’s Pilgrim fathers in the early 17th century. Today, lovely Leiden boasts the second-largest Dutch city center after Amsterdam. The National Museum of Antiquities has an impressive collection of Egyptian artifacts. The Hortus Botanicus, established in 1590, was the site of the planting of Holland’s first tulip bulbs in 1593.