You didn't mention how small your kids are. The hotel is on a busy street and it's a pretty good hike to the actual UVA campus (closer to the med center). There are sidewalks, but you are walking by parking lots, businesses, and through some big intersections. Definitely not walking distance to the Downtown Mall. The Hampton Inn is a decent place to stay, but I would limit walking to the UVA campus to the daylight hours. Plan ahead what you want to see at the UVA campus, it's quite a large campus. While West Main St, where the hotel is located, has many restaurants, Wild Wings is probably the most kid friendly. It's down near the Amtrack station. Teens and older love eating on the Corner (UVA campus) at places like the College Inn, but even with the regular college session out, the area can get pretty rowdy in the evening with all the local kids home for the summer. The Downtown Mall (a pedestrian friendly brick outdoor mall) has a lot of outdoor eateries, the Virginia Discovery Museum (for children), and the indoor ice skating park. Henry's on the Downtown Mall has traditional family restaurant fare that kids love and has indoor/outdoor seating. Sal's is Italian and Christian's and Vito Nova have great pizza. Another kid friendly place to eat if you get there early enough for a booth seat is Chap's, where you can get a burger/hot dog/grilled cheese and homemade icecream is a treat. Splendora's has Italian gelato. The Nook serves traditional breakfast with a number of coffee/tea spots also serving muffins and pastries. The Omni is a Mall anchor with an indoor pool. On Sundays they serve brunch with serving section dedicated to children. Check out www.downtowncharlottesville.net with a list of places and things to do in the downtown area. Monticello is easy to get to and not far from downtown. If you're so inclined, there are a number of hiking opportunities as well. You can check former posts for good descriptions.